AKT1 and breast carcinoma: Pharmacodynamic interactions can be desirable, as seen in synergism between actein and digitoxin, where actein improves the growth inhibitory effect of digitoxin on human breast cancer cells through the inhibition of Na+–K+-ATPase activity [14]; the verbascoside and 5-Fluorouracil synergistic cytotoxic interaction significantly reduces PI3K and the p-AKT/total AKT ratio and causes G1 cell cycle arrest in colorectal cells [15].