Investigation of the expression of FDC markers in HL and anaplastic large cell lymphoma (ALCL) revealed GLI3, fascin (actin-bundling protein found in membrane ruffles), and TUBB3 (a member of the beta-tubulin protein family) as the most sensitive markers, which were diffusely positive in HL [238]. The gene discussed is GLI3; the disease is Hodgkins lymphoma.