Our present work demonstrates for the first time that FAP expression positively correlates with TGFbeta expression in glioblastomas and can be differentially regulated via autocrine and paracrine TGFbeta-1 signaling in non-stem glioma cells, pericytes, glioblastoma-derived endothelial and FAP+ mesenchymal cells, but not in glioma stem-like cells. This evidence concerns the gene TGFB1 and central nervous system cancer.