Permanent human glioma cell lines U87, U251 and U118 displayed detectable baseline FAP enzymatic activity and FAP protein which dose-dependently increased when the cells were cultured in the presence of TGFbeta-1 at concentrations ranging from 0.2 ng⋅mL−1 to 10 ng⋅mL−1 (Figure 4A and Figure 5). The gene discussed is FAP; the disease is central nervous system cancer.