The percentage proportions of large adenoma (> 4 mm diameter) and medium-sized adenoma (2–4 mm) were greatly reduced in Apcmin/+; Crhr1−/− mice compared to those of littermate Apcmin/+; Crhr1+/− and Apcmin/+; Crhr1+/+ mice (Figure 2E). The gene discussed is CRHR1; the disease is adenoma.