CRHR1 and adenoma: However, the mRNA levels of tumor-associated genes, including Vegf-a, interleukin 6 (Il6), and tumor necrosis factor α (Tnfα), were comparable in all adenomas from Apcmin/+; Crhr1−/−, Apcmin/+; Crhr1+/−, and Apcmin/+; Crhr1+/+ mice.