Taken together, these data indicate that a blockade of CRHR1-mediated responses should inhibit the expression of Cox2, and upregulate the expression of Pla2. Thereby, Crhr1 gene deficiency is capable of not only suppressing the tumor development and growth, but also ameliorating the disease severity, at least in the Apcmin/+ mouse model of intestinal tumorigenesis. This evidence concerns the gene PTGS2 and neoplasm.