TNF and colitis: In that study, the authors showed that the tumor tissues have decreased levels of inflammatory cytokines such as Il6 and Tnfα. It is worth noting that the tumor development and growth in the AOM/DSS model is elicited by the degree of DSS-induced colitis; the microbiome in mice and microbial environment in an animal housing facility heavily influence the severity of DSS-induced mouse colitis.