LRRK2 and Parkinson disease: Using a PD PRS from 89 variants reported, a large cohort of heterozygous LRRK2 p.G2019S mutation carriers (833 LRRK2 p.G2019S carriers: 439 PD and 394 unaffected) was analyzed, and the PD PRS was associated with a higher penetrance of PD (OR: 1.34; p = 0.005).