Interestingly, relatives of LRRK2-PD (n = 142, independent of mutation carrier status) present with a worse motor score and anxiety compared to 172 controls, implying that other environmental or non-LRRK2 genetic modifiers might influence the penetrance of LRRK2 p.G2019S-PD [87]. Here, LRRK2 is linked to Parkinson disease.