After early reports of LRRK2 neuropathology in human postmortem cases, it became apparent that LRRK2 parkinsonism presents with heterogeneous neuropathology, including pure nigral–striatal degeneration or typical LB pathology, but also cases with multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) staining with variable concomitant Alzheimer’s pathology [55,101,102]. The gene discussed is LRRK2; the disease is progressive supranuclear palsy.