However, a follow-up study of an overlapping cohort analyzed novel HRV parameters and showed that there was more vagal involvement in 14 LRRK2-PD compared to 27 healthy controls and even in a subset of LRRK2 non-manifesting carriers (a total group of 25 non-manifesting LRRK2 carriers), suggesting a preclinical endophenotype of impairment of cardiac innervation [91]. Here, LRRK2 is linked to Parkinson disease.