While the clinical presentation of motor symptoms of LRRK2 parkinsonism has been largely indistinguishable from sporadic PD, there is a striking difference in the age at onset (AAO), disease penetrance, and neuropathological features, ranging from nigrostriatal loss with inconsistent occurrences of Lewy body (LB) and Alzheimer’s pathology, lack thereof, or atypical neuropathology. The gene discussed is LRRK2; the disease is Parkinsonism.