In resting-state magnetic resonance imaging (MRI), there was reduced integrity of nonmotor networks detected in asymptomatic LRRK2 p.G2019S (n = 44) compared to asymptomatic non-LRRK2 carriers (n = 41) before changes in the connectivity of the motor network were present, which illustrates that nonmotor cerebral changes delineate LRRK2 p.G2019S carriers as “at risk” for developing PD [93]. This evidence concerns the gene LRRK2 and Parkinson disease.