After early reports of LRRK2 neuropathology in human postmortem cases, it became apparent that LRRK2 parkinsonism presents with heterogeneous neuropathology, including pure nigral–striatal degeneration or typical LB pathology, but also cases with multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) staining with variable concomitant Alzheimer’s pathology [55,101,102]. Here, LRRK2 is linked to Parkinson disease.