PIK3CA and inflammatory breast carcinoma: For example, amplification of oncogene protein c-MYC, protein IK3 oncogene (PIK3CA), human estrogen receptor (HER)2 and fibroblast growth factor signaling pathway (FGFR1), and mutation of suppressor protein (p53), breast cancer susceptibility alleles (BRCA)2 and tumor suppressor gene with protein and phosphatase activity (PTEN), were detected in individuals with inflammatory breast cancer (IBC).