Many GPR119 agonists, such as GSK1292263, APD668, APD5997, MBX-2982, BMS-903452, LEZ763, ZYG-19, and PSN821, have been developed for type 2 diabetes and obesity [53,54,55,56,57]. Here, GPR119 is linked to obesity due to melanocortin 4 receptor deficiency.