CTLA4 and cancer: Several such approaches have been developed, including vaccine therapy [14], chimeric antigen receptor (CAR) T cells [15], and immune checkpoint inhibitors (ICI) like antibodies against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) [16], programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) [17,18,19], and are currently used in clinical practice for the treatment of several cancers, including lung cancer [20].