IGF1 and neoplasm: It is well documented that stromal cells in pancreatic cancer account for more than 80% of the total tumor volume and secrete a number of signaling molecules including fibroblast growth factor (FGF), epidermal growth factor (EGF), VEGF, TGFβ and insulin-like growth factor I (IGF-I) as well as matrix metalloproteinases (MMPS) [180].