SCN8A and infantile epileptic encephalopathy: Nav1.6, distributed in the central and peripheral nervous systems, has been previously reported to be related to infantile epileptic encephalopathy (46, 47, 48), and recent studies have reported that the gain-of-function mutation of Nav1.6 increased trigeminal ganglia neuron excitability in trigeminal neuralgia (49), whereas Nav1.6 knockdown ameliorated mechanical pain behavior in models of local inflammation and neuropathic pain (50, 51).