Conversely, in type 2 diabetes mellitus model, a hyper-insulin environment, both in vivo and in vitro experiments indicate that KLF5 attenuates VEGF-induced endothelial migration and proliferation and compromises angiogenic function by inhibiting the expression of NOS3 (Wang et al., 2019c). The gene discussed is NOS3; the disease is type 2 diabetes mellitus.