Besides, KLF5 promotes breast cancer angiogenesis in part through TNF-α-induced protein 2 (TNFAIP2), an angiogenetic factor increasing capillary tube formation, and KLF5 positively regulates TNFAIP2 by directly binding to its promoter (Jia et al., 2018). Here, TNFAIP2 is linked to breast carcinoma.