Clinically, mutations in SARS-CoV-2-S have been identified (Supplementary Figure S3 and Table S2), and COVID-19 cases carrying V367F mutation in SARS-CoV-2-S, which contacting KIM1, have been reported (http://giorgilab.dyndns.org/coronapp/, summarized in Supplementary Figure S3B and C) (Mercatelli et al., 2020). This evidence concerns the gene HAVCR1 and COVID-19.