We also found that SARS-CoV-2-RBD binds to KIM1 with a higher affinity than that of SARS-CoV-RBD and MERS-COV-RBD, which probably underlies the stronger contagion of SARS-CoV-2 (Rabaan et al., 2020); therefore, the renal infection and the roles of KIM1 in these severe respiratory diseases worth revisiting. Here, HAVCR1 is linked to respiratory system disorder.