CD8A and gout: After quality control (Supplementary Figure 1, Step I), CellDMC analysis identified 1,763 cytosine-phosphate-guanine dinucleotide (CpG) sites across promoter (TSS200, TSS1500) [22], 5'UTR, gene body, 3'UTR, and intergenic regions exhibited differential methylation in monocytes, eosinophils, neutrophils, NK cells, B cells, CD4+ T cells, and CD8+ T cells in gout patients after correcting for sex, age, alcohol drinking, smoking status, smoking history (total pack-years), and cell fractions [20] (Supplementary Table 2).