Genomic amplification in 11q13 region was previously reported to associate with poor response to toripalimab in melanoma14 and esophageal squamous cell carcinoma.38 Overexpression of CCND1, FGF, and ETV6 genes has been correlated with poor prognosis in patients with NPC.39,40 The impact of genomic amplification in 11q13 region and ETV6 on immune function and immunotherapy needs to be further investigated. The gene discussed is ETV6; the disease is esophageal squamous cell carcinoma.