Most of the animal studies were performed in C57BL/6 J mice immunized with MOG35–55, a chronic animal model of MS which resembles primary and secondary progressive MS, and which mostly involves CD8+, CD4+, Th17, and regulatory T cells, B cells, as well as monocytes and macrophages (Procaccini et al. 2015; Kipp et al. 2017). This evidence concerns the gene CD4 and myeloid sarcoma.