CD4 and Autoimmunity: Moreover, no studies so far tested CBD on the differentiation and function of CD4+ T cell lineages such as leading to autoimmunity in MS, such as Th1 and Th17, or playing protective roles, such as Th2 and Treg, despite preliminary evidence that CBD may downregulate molecular pathways leading to Th17 (Kozela et al. 2016a).