When performing quantification of CK1ε, VXN, TOMM34 and PPIB using immunoblotting on whole hippocampal lysates of 7 control cases versus 6 AD cases, no significant change in abundance was found (Fig S4), indicating that immunoblotting of whole hippocampal lysates does not provide sufficient resolution to match the laser-dissected cellular proteomics approach. This evidence concerns the gene VXN and Alzheimer disease.