C9orf72 and multiple system atrophy: GVD is also present in Down’s syndrome and primary tauopathies [44, 61, 64], as well as frontotemporal dementia cases with C9orf72 mutations and alpha synucleinopathies, such as Parkinson’s disease (PD), Lewy body dementia (LBD) and multiple system atrophy (MSA) [18, 37, 57].