Interestingly, despite standard therapeutic doses of anticoagulation, we only reached “mild” anticoagulation targets (median aPTT ratio 1.4 [1.2; 1.7] and median anti-Xa 0.30 [0.18; 0.43] IU/mL), emphasizing the difficulties to anticoagulate COVID-19 patients due to procoagulant feature and heparin resistance [1, 24]. The gene discussed is TNXA; the disease is COVID-19.