In univariate analysis, prognostic factors positively associated with OS included being younger than 60 at initial diagnosis of HNSCC (p = 0.005), ≤ 50 copies in HIV-PCR (p = 0.005), CD4 cell count > 200 (p < 0.001), under cART treatment (p = 0.005), early tumor stage in T classification (p = 0.006) and UICC classification (p = 0.012), tumor sites oral cavity (p = 0.046), and nasal/paranasal sinuses (p = 0.002) and tumor therapy (surgical treatment only vs. all other treatments, p = 0.023). Here, CD4 is linked to head and neck squamous cell carcinoma.