PPP1R15A and acute kidney injury: The phosphatase PPP1R15A is only expressed in stressed cells and negatively regulates acute kidney injury via type 1 interferon;54 clonal expansion; and memory T-cell, plasma cell differentiation, and enhanced B-cell responses.55FOSB expression is associated with the progression of kidney disease.56 Thus, all InstaScore genes are crucial for endothelial cell integrity, and T-cell activation, and have functional relevance to the kidney and rejection.57,58