These group A+CM PfEMP1s are characterized by the presence of a particular motif in their ICAM-1–binding sub-domain (DBLβ), which is absent in non–ICAM-1–binding EPCR–adherent IEs, and in DBLβ of ICAM-1–binding group B and C PfEMP1s (group BUM and CUM; Fig. S1, B and C) associated with uncomplicated malaria (UM; Lennartz et al., 2017; Olsen et al., 2019; Turner et al., 2013). This evidence concerns the gene PROCR and malaria.