PROCR and systemic mastocytosis: Since the identification of endothelial protein C receptor (EPCR)–binding parasites expressing group A and group B/A DC8 PfEMP1s and their association with severe malaria (SM; Moxon et al., 2013; Turner et al., 2013), parasites associated with severe disease can be further characterized to a subset causing CM (Fig. S1 B).