demonstrated that HSP90AA1 was up-regulated during chemotherapy in osteosarcoma patients, which promoted autophagy and inhibited apoptosis through PI3K/Akt/mTOR pathway and JNK/p38 pathway respectively, so as to promote the chemotherapeutic resistance of osteosarcoma both in vivo and in vitro [30]. Here, MAPK8 is linked to osteosarcoma.