CASP3 and neoplasm: Analyzing the homogenates from tumor tissues shown in Supplemental Figure 9A that were treated with PS-acet.-STAT3 peptide confirmed the decreased STAT3 activation and increased expression of apoptotic proteins, p53 and cleaved caspase-3, as well as the proapoptotic gene (CASP9), as analyzed by Western blotting and quantitative real-time PCR, respectively (Supplemental Figure 9, B, C, and E).