Further, in contrast to normal colorectal tissues, STAT3 acetylation was highly elevated in colorectal tumor tissues, as shown by fluorescent IHC staining of human colorectal tumor tissue array and 1 colorectal cancer (CRC) patient-derived xenograft (PDX) tumor tissue (Supplemental Figure 8, A and B, respectively). This evidence concerns the gene STAT3 and colorectal neoplasm.