Importantly, an IFNγ‐induced PD‐L1high/MHC class I moleculeshigh/NKG2D ligandslow phenotype is optimal for cancer cells to escape NK cells, since NK cells are inactivated by PD‐L1 and MHC class I molecules, while they are activated by NKG2D ligands on cancer cells. The gene discussed is KLRK1; the disease is cancer.