We found evidence of a small effect of TRAIL on CAD with OR of 1.03 (95% CI: 1.00‐1.06; P = 0.04) using the CARDIoGRAMplusC4D GWAS data but no apparent effect when using the smaller European‐only CARDIoGRAM GWAS data (OR 1.00; 95% CI: 0.94‐1.07; P = 0.91) (Figure 3, Supporting Information Figure S7 and Table S18). The gene discussed is TNFSF10; the disease is coronary artery disorder.