The complex relationship of TRAIL with CAD may be due to the existence of different receptor types that either initiate apoptosis (TRAIL‐R1/DR4 and R2/DR5) or promote apoptosis by acting as decoy proteins for TRAIL binding (TRAIL‐R3/DcR1, R4/DcR2, and osteoprotegerin) (40). The gene discussed is TNFRSF11B; the disease is coronary artery disorder.