CD4 and major depressive disorder: PLHIV with and without anxiety both experienced a decrease in CD4 the study period (13.4 cells/mm3 and 48.6 cells/mm3 respectively), however this decline was even greater among those with anxiety, with a difference of 35.27 cells/mm3 (beta=−35.27, 95% CI=−55.80,−14.70), which was similar to the change among PLHIV with depression (Table 4).