PLHIV with depression had higher prevalence of underweight BMI (13.1% vs. 4.7%, p<0.01) and a 67 cells/mm3 lower median CD4 T-cell count (vs. 262 cells/mm3 vs. 329 cells/mm3, p<0.01) compared to those without depression (Table 2). This evidence concerns the gene CD4 and major depressive disorder.