CD4 and major depressive disorder: PLHIV with and without depression both experienced a decrease in CD4 count during the study period (11.6 cells/mm3 and 51.4 cells/mm3 respectively), however this decline was even greater among depressed, with a difference of 39.8 cells/mm3 (beta=−39.8, 95% CI=−57.8, −21.8) (Table 4).