The increase in macrophages was attenuated by electrically stimulated quadriceps contractions starting at the onset of knee osteoarthritis.76 Also, treadmill training blocked the increases in pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6), increases in chemokine CCL2,65 and decreases in anti-inflammatory cytokines (IL-4, IL1ra, and IL-10) that are found in the sciatic nerve after induction of neuropathic pain.11,12,26,28,72,154 Furthermore, sciatic nerve injury was found to alter macrophage distribution in the sciatic nerve. The gene discussed is TNF; the disease is osteoarthritis, knee.