,40 Pike et al41 recently reported that among men with localized disease treated with RT who did not achieve PSA level < 0.2 ng/mL, time to nadir PSA of less than 12 months was significantly associated with an increased prostate cancer specific mortality compared with patients with time to nadir PSA ≥ 12 months; this association was not observed among men with a PSA nadir of < 0.2 ng/mL.41 This evidence concerns the gene KLK3 and prostate carcinoma.