NOTCH2 and B-cell non-Hodgkin lymphoma: In RAJI cells (Burkitt lymphoma) and SLVL cells (splenic B cell lymphoma), mutations of DNA-binding protein inhibitor ID-3 (ID3), transcription factor 3 (TCF3), and neurogenic locus notch homolog protein 2 (NOTCH2) increase phosphorylation of proteins in Akt/mTOR pathway [48, 49, 50].