GRN and acute promyelocytic leukemia: Because over 80% of newly diagnosed patients with hematopoietic malignancies suffer from lymphoma and leukemia [29], cell lines such as Daudi (Burkitt lymphoma), HL60 (acute promyelocytic leukemia), Kasumi-1 (acute myeloid leukemia), RAJI (Burkitt lymphoma), and SLVL (splenic B cell lymphoma) were used to investigate the role of progranulin in the proliferation of human hematopoietic cancer cells.