ARF6 and Autoimmunity: The protein encoded by this gene plays an important role in the regulation of endosomes trafficking. It may regulate autophagy-related mechanics. Also, it regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation. Positively regulates axon extension and axon growth cone size in spinal motor neurons. It plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity.