The activation of GSK-3β accounts for several features of AD such as increased Aβ production and plaque accumulation [407], reduced memory performance, neurogenesis and synaptogenesis (astroglial-related) [395],[408], as well as increased Tau phosphorylation, Inflammation (microglia) and neurodegeneration (mitochondrial intrinsic apoptotic and the death receptor-mediated extrinsic apoptotic pathways) [409]. Here, MAPT is linked to Alzheimer disease.