SORL1 and Alzheimer disease: This gene encodes protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. Its role is likely related to endocytosis mechanics. SORL1 seems to be also associated with Alzheimer endophenotypes such as abstract thought, verbal memory, total brain volume, and white matter hyperintensities among people AD free. Regarding its mechanics SORL1 is believed to act through the regulation of the APP-containing endocytic vesicles trafficking.