The protein encoded by this gene is a major apoprotein of the chylomicron and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This protein Mediates the binding, internalization, and catabolism of lipoprotein particles and can serve as a ligand for the LDL (Apo B/E) receptor. Mutations in this gene result in an impaired clearance of chylomicron and VLDL remnants. Further, several evidences in literature associate specific APOE isoforms with an increased risk of Alzheimer disease. The gene discussed is APOE; the disease is Alzheimer disease.