The high expression of DHX37 was significantly associated with unfavorable prognosis in esophageal adenocarcinoma (P = 0.0055), kidney renal clear cell carcinoma (P = 0.0011), liver hepatocellular carcinoma (P = 0.025), lung adenocarcinoma (P = 0.00095), head-neck squamous cell carcinoma (P = 0.017), and sarcoma(P = 0.0014). Here, DHX37 is linked to esophageal adenocarcinoma.