A cohort study with 5354 nondiabetic participants in Korea followed for 4.6 years firstly showed that, compared to participants in the lowest quartile of TyG, participants in the highest quartile of TyG had a higher risk of diabetes (relative risk 4.095; 95% CI 2.701-6.207) after adjusting for age, gender, BMI, WC, SBP, HDL-cholesterol, a family history of diabetes, smoking, alcohol drinking, education, and insulin [15]. The gene discussed is INS; the disease is diabetes mellitus.