As is shown in Figure 2, in the total population (n = 799), the performance of AFP (AUC: 0.725; 95% CI 0.691-0.756) was significantly lower than that of AFP/(ALT × AST) (AUC: 0.769; 95% CI 0.737-0.799) in the diagnosis of HCC (P < 0.001; Figure 2(a)). The gene discussed is AFP; the disease is hepatocellular carcinoma.