In multivariable analysis, only the serum ALT level (P < 0.001) and gamma-glutamyl transferase level (P = 0.02) were significantly associated with the abnormally elevated serum AFP level in patients with hepatitis B. The increased serum ALT level was significantly correlated with the abnormally elevated AFP level (Rs = 0.395, P < 0.001) using Spearman's rank correlation coefficient. Here, GPT is linked to hepatitis B virus infection.