Liu et al. first used this novel index AFP/(ALT × AST) ratio in their study and found that the diagnostic value of the AFP/(ALT × AST) ratio was significantly better than that of AFP, with AUC up to 0.853 (95% CI 0.818–0.887) and 0.825 (95% CI 0.782–0.868) for differentiating HCC from non-HCC patients and from cirrhosis patients, respectively [19]. Here, AFP is linked to hepatocellular carcinoma.