The median value of the serum AFP level in the cirrhosis group with a serum ALT level > 2 ULN was significantly higher than those with a serum ALT level ≤ 2 ULN (P < 0.001) whereas there was no significant difference between the median values of AFP levels in the cirrhosis group with a normal serum ALT level and those with 1 ULN < serum ALT level ≤ 2 ULN (P = 0.73). This evidence concerns the gene AFP and Cirrhosis.