Its dysregulation is associated with aberrant signal transduction in various cellular pathways in cancers such as STAT3 in glioblastoma [21], phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB) (also known as Akt) in prostate cancer, and Notch signaling pathway in gastric cancer [22]. This evidence concerns the gene AKT1 and prostate cancer.