KDR and type 1 diabetes mellitus: In addition to an alteration in VEGF production, a lower expression and/or activation of its receptor VEGFR2 were reported in the 28-day ischemic muscle of db/db T2D mice (38) as well as in streptozotocin (STZ)-induced T1D mice 3, 14 and 28 days post HLI-surgery, respectively (39–42).