CD155 is a member of the nectin-like family of adhesion molecules that has a wide variety of functions relevant to cancer, including tumor cell-intrinsic activities that regulate proliferation, adhesion, and migration as well as the ability to affect immune responses by binding to the immunomodulatory receptors DNAM-1, CD96, and TIGIT (Li et al., 2018). The gene discussed is NECTIN1; the disease is cancer.