For example, increasing concentrations of serum S100 calcium-binding protein B (S100B), lactate dehydrogenase (LDH), melanoma-inhibiting activity (MIA), YKL40 and tumor-associated antigen 90 immune complex (TA90IC) are all strongly associated with overall survival, suggesting their function as prognostic factor in late-stage malignant melanoma (Gogas et al., 2009). The gene discussed is CHI3L1; the disease is melanoma.