Linked by a network of overlapping functions in melanoma progression, melanoma cell adhesion molecule (MCAM), galectin-3 (Gal-3), chondroitin sulfate proteoglycan 4 (CSPG4), matrix metalloproteinase 2 (MMP-2), and paired box 3 (PAX-3) potentially act as biomarkers and targets in melanoma metastasis (Dye et al., 2013). The gene discussed is PAX3; the disease is melanoma.