TRPC6 and brain ischemia: Although TRPC6 expression in mouse cortical neurons has been reported to be increased following brain ischemia/reperfusion in vivo and OGD/reoxygenation in vitro, and this increase contributed to neuronal injury in an NMDA receptor-dependent manner (Chen J. et al., 2017), nearly all other studies argue for a protective role of TRPC6 in neurological damage associated with ischemic stroke.