How this function of TRPC3/6/7, which promotes the death of astrocytes, is related or coordinated with astrogliosis, an abnormal proliferation of brain astrocytes observed after stroke and shown to be positively regulated by TRPC3 (Shirakawa et al., 2010; Munakata et al., 2013; Belkacemi et al., 2017), is an interesting question that needs to be addressed in future studies. The gene discussed is TRPC3; the disease is Stroke.