In status epilepticus, TRPC6 serves to protect granule neurons of dentate gyrus from degeneration through activation of ERK1/2 and the subsequent phosphorylation of dynamin-related proteins 1 (DRP1) at Ser-616 (Ko and Kang, 2017) and an increase in the expression of a mitochondrial protease, Lon protease-1 (Kim et al., 2019). The gene discussed is DNM1L; the disease is status epilepticus.