In a very recent study, TRPC5 was found to directly interact with phospholipid scramblase 1 (PLSCR1) on the plasma membrane to facilitate externalization of phosphatidylserine (PS) and apoptosis of cortical neurons in response to cerebral ischemia/reperfusion (Guo et al., 2020). Here, PLSCR1 is linked to Cerebral ischemia.