The beneficial effect of TRPC6 to Alzheimer’s disease was demonstrated by showing that stimulating TRPC6 or the store-operated Ca2+ entry improved hippocampal long-term potentiation of the APP-presenilin 1 mutant mice, an experimental model of Alzheimer’s disease (Zhang et al., 2016; Popugaeva et al., 2019). This evidence concerns the gene TRPC6 and early-onset autosomal dominant Alzheimer disease.