These include the ZEB2 transcription factor essential for maintenance of leukemic growth in AML (Li et al., 2017), LCN2 lipocalin whose ectopic expression promotes leukemogenesis (Chakraborty et al., 2012), and other genes previously linked to AML (RARA, CCND1, and NFKB1). Here, ZEB2 is linked to acute myeloid leukemia.