Pairwise comparisons of individual JMML subgroups to HD revealed 29 circRNAs dysregulated in KRAS, 34 in NRAS, 7 in PTPN11 and 25 in NF1, with 11 circRNAs dysregulated in two or three different JMML molecular subtypes. The gene discussed is PTPN11; the disease is juvenile myelomonocytic leukemia.