In total, 119 circRNAs were differentially expressed of which 37 significantly taking all JMML samples together and 83 when comparing each molecular subtype with HD (29 dysregulated in KRAS, 34 in NRAS, 7 in PTPN11 and 25 in NF1). The gene discussed is PTPN11; the disease is juvenile myelomonocytic leukemia.