A subset of pancreatic adenocarcinomas are characterized by a high expression of MITF, TFE3, and TFEB genes (Levy et al., 2006; Kauffman et al., 2014; Perera et al., 2015, 2019; Raben and Puertollano, 2016), whereas some renal cell carcinomas and alveolar soft sarcomas show chromosomal translocation of TFEB and TFE3 genes, leading to the formation of chimeric proteins or fusion of their coding regions with strong regulatory elements of unrelated genes resulting in the upregulation of the MiT/TFE gene network (Kuiper et al., 2003; Xie et al., 2019). The gene discussed is TFE3; the disease is pancreatic adenocarcinoma.