While the MDA-MB231-GPS2KO model is not ideal for investigating these predictions as TNBC cells are already characterized by high glycolytic activity and low mitochondrial respiration (Lanning et al., 2017; Guha et al., 2018; Sun et al., 2020), we did observe significant changes in the expression of key mitochondrial proteins suggesting that the loss of GPS2 could in fact be contributing to promote the metabolic reprogramming of rapidly growing cancer cells. This evidence concerns the gene GPS2 and cancer.