In addition, Ca2+ signaling is known to regulate migration of normal and breast cancer cells (Wei et al., 2009; Iamshanova et al., 2017) and certain mechanosensitive Ca2+ channels, particularly the Transient Receptor Potential (TRP) and Orai1 families, are overexpressed in breast cancer and associated with poor clinical prognosis (Bolanz et al., 2008; Dhennin-Duthille et al., 2011). The gene discussed is ORAI1; the disease is breast cancer.