Similarly to CLL, in AML the promoter of genes coding for Wnt antagonists (sFRP1, sFRP2, sFRP4, sFRP5, DKK1, and DKK3 etc.)are frequently methylated predicting poor outcome in patients (Jost et al., 2008; Valencia et al., 2009). Here, DKK3 is linked to acute myeloid leukemia.