NOTCH1 and acute lymphoblastic leukemia: – Notch1 is mutated in more than 50% of patients (Weng et al., 2004). – Notch signaling drives oncogenesis and supports growth and survival of T-ALL cells (Weng et al., 2004; O’Neil, 2006). – Notch 3 supports survival of T-ALL cells (Masiero et al., 2011).