LEF1 and B-cell chronic lymphocytic leukemia: – Activation of Notch signaling supports growth and survival of CLL cells (Kamdje et al., 2012; Rosati et al., 2013). – Lef1 is a prosurvival factor s (Willander et al., 2013). – Wnt/PCP controls migration of CLL cells (Janovska et al., 2016).