– Notch/Jagged1 expression and activation in acute promyelocytic leukemia (APL) supports leukemia cell growth (Grieselhuber et al., 2013). – Activation of Wnt/β-catenin/TCF/LEF pathway supports growth of leukemia cells (Khan and Bendall, 2006). – Epigenetic modification of Wnt inhibitors in AML (Griffiths et al., 2010). The gene discussed is JAG1; the disease is acute myeloid leukemia.