Consistently the promoter of genes coding for Wnt pathway inhibitors including WIF1, DKK3, APC, SFRP1, SFRP2, SFRP4, and SFRP5 are frequently hypermethylated and consequently downregulated in samples from CLL and ALL (Roman-Gomez et al., 2004; Martin et al., 2008; Rahmatpanah et al., 2009). The gene discussed is SFRP2; the disease is B-cell chronic lymphocytic leukemia.