– Higher expression and activation of Notch signaling is observed in refractory patients (Kamdje et al., 2011; Takam Kamga et al., 2019b). – Wnt ligands and receptors are overexpressed in B-ALL cells (Khan et al., 2007). – Overexpression of LEF1 predicts poor outcomes (Kühnl et al., 2011). The gene discussed is LEF1; the disease is precursor B-cell acute lymphoblastic leukemia.