FZD8 and precursor B-cell acute lymphoblastic leukemia: In B-ALL cell lines and primary B-ALL cells, the Wnt pathway is activated by over-expression of Wnt proteins and receptors (Wnt-2b, Wnt-5a; Wnt-10b, Wnt-16b; FZD7; FZD8) and their stimulation with Wnt-3a increases the survival and proliferation of these cells (Khan et al., 2007).