SNCA and Alzheimer disease: Furthermore, nanoscale analysis performed on postmortem brain tissue slice of patients affected by AD and PD showed that beta-amyloid and alpha-synuclein inclusions were enriched in lipid membranes and organelles structurally resembling lysosomes and in part immune-reactive for lysosomal markers (Nixon et al., 2005; Hassiotis et al., 2018; Shahmoradian et al., 2019).