SQSTM1 and amyotrophic lateral sclerosis: Genetic variants of the autophagy receptors OPTN and SQSTM1 are linked to ALS-FTLD (Fecto et al., 2011; Deng et al., 2017), and more severe disease forms are caused by mutations in the UBA domain of P62 (Fecto et al., 2011; Kwok et al., 2014).