Transcriptional misregulation in a cancer pathway was identified to be significant and found to involve 16 genes: HIST1H3D, HIST1H3B, HIST1H3F, HIST2H3D, CSF2, TLX3, HIST1H3A, HIST1H3E, IGFBP3, ETV7, WNT16, SLC45A3, GADD45A, ID2, TSPAN7, NFKBIZ, and IGF1. This evidence concerns the gene IGFBP3 and cancer.