In order to study the mechanism of LINC00675 down-regulation in HCC, bioinformatical software program JASPAR (http://jaspar.genereg.net/cgi-bin/jaspar_db.pl) was carried out to analyze the promoter regions of LINC00675, and three potential sites of GFI1 binding were predicted. This evidence concerns the gene GFI1 and hepatocellular carcinoma.