Mumblat Yelena et al. showed that PLXND1 was involved in inducing the collapse of the cytoskeleton of lymphatic endothelial cells (LEC), and impacted tumor lymphangiogenesis and metastasis (13): however, until recently, little was known about the abnormal expression and function of PLXND1 in HCC. Here, PLXND1 is linked to hepatocellular carcinoma.