The induction of angiopoietin-like 4 (ANGPTL4) by transforming growth factor-beta (TGFβ)/small mother against decapentaplegic (SMAD) signaling pathway in cancer cells is reported to enhance their subsequent retention in the lungs and empower breast cancer cells to destroy lung capillary wall and form pulmonary metastases (90). The gene discussed is TGFB1; the disease is breast carcinoma.