HIF-1α has recently been shown to increase the expression levels of pro-collagen prolyl (P4HA1 and P4HA2) and lysyl (PLOD1 and PLOD2) hydroxylases in both tumor and stromal cells, thereby enhancing cancer cell alignment along collagen fibers, thereby promoting invasion and metastasis to lymph nodes and lungs (253–255). This evidence concerns the gene HIF1A and cancer.