Cancer-asscociated fibroblasts (CAFs), the paramount stromal cells in breast tumor microenvironment, contribute to tumor progression through many mechanisms, such as releasing of assorted secretory proteins (e.g. TGF-β, IGF, and IL6), direct interplaying with tumor cells, regulating immune-response, ECM remodeling, and inducing cancer metabolic reprogramming (271). The gene discussed is IGF1; the disease is cancer.