Furthermore, upregulating MAPK8IP1P2 enhanced the expression of phophorylated MST1/2 (p-MST1/2), phophorylated LATS1 (p-LATS1) and phophorylated YAP1 (p-YAP1), reduced the nuclear translocation of YAP1 and TAZ, but had no effect on total level of MST1 and LATS1 in thyroid cancer cells (Figure 5C). This evidence concerns the gene LATS1 and thyroid cancer.