MAPK8IP1P2 and metastatic malignant neoplasm in the lymph nodes: Our results further indicated that MAPK8IP1P2 expression in thyroid cancer tissues without lymph node metastasis had no significant difference compared with that in ANT (Figures 1C, D), but was dramatically and significantly downregulated in thyroid cancer tissues with lymph node metastasis (Figure 1C), even in lymph node metastatic thyroid cancer tissues with T1-T2 (Figure 1D).