Inactivation of Hippo signaling has been widely reported to be implicated in anoikis resistance and metastatic thyroid cancer (9, 50, 51), as well as in lymphatic metastasis process of cancers (52, 53), suggesting that Hippo signaling may mediate the functional role of MAPK8IP1P2 in lymphatic metastasis of thyroid cancer. The gene discussed is MAPK8IP1P2; the disease is cancer.