In summary, our results demonstrate that MAPK8IP1P2 activates Hippo signaling by sponging miR-146b-3p as a ceRNA to disrupt the inhibitory effect of miR-146b-3p on NF2, RASSF1, and RASSF5 expression, which further suppresses lymphatic metastasis of thyroid cancer. Here, MAPK8IP1P2 is linked to thyroid cancer.