In the current study, our results showed that MAPK8IP1P2 activated Hippo signaling by sponging miR-146b-3p to disrupt targeting effect of miR-146b-3p on NF2, RASSF1, and RASSF5, which inhibited anoikis resistance and lymphatic metastasis of thyroid cancer. This evidence concerns the gene RASSF5 and thyroid gland carcinoma.