Importantly, miR-146b-3p mimics not only reversed the NF2, RASSF1, and RASSF5 level enhanced by MAPK8IP1P2 overexpression (Figures 6H, I), but also inactivated Hippo signaling in MAPK8IP1P2-overexpressing thyroid cancer cells as indicated by elevated the luciferase reporter activity of HOP-Flash (Figure 6J). The gene discussed is MAPK8IP1P2; the disease is thyroid gland carcinoma.