Real-time PCR analysis showed that upregulating MAPK8IP1P2 decreased, while silencing MAPK8IP1P2 increased the expression levels of multiple downstream genes of Hippo pathway, including CTGF, CYR61, HOXA1, PPIA, RPL13A, and SOX9 (54, 55), in thyroid cancer cells (Figure 5D). The gene discussed is CCN2; the disease is thyroid gland carcinoma.