The 11 GRGs identified in this study included PGK1, SDC1, NUP43, NT5E, IL13RA1, GCLC, CACNA1H, P4HA1, TSTA3, MXI1, and STC1. Of these genes, PGK1 (phosphoglycerate kinase 1) has been identified to promote BC progression and metastases via forming a positive feed-forward loop with HIF-1α. This evidence concerns the gene P4HA1 and breast cancer.