The study retrospectively matched clinical, molecular and imaging databases of seven patients with histologically proven EGFR-positive NSCLC (exon 19 deletion [ex19del], exon 21 [L858R], or other mutations [i.e. L861Q]), and candidate to a first/second or third-generation EGFR-TKIs. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.